A single-cell atlas of non-alcoholic fatty livers identifies regulatory genes that control de novo lipogenesis

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Answer 1

A Final statement or concluding statement

It should be noted that not all gut microbiota promote fatty liver disease; some strains act as "probiotics," mitigating the negative effects of other gut microflora.

This is supported by evidence that butyrate, as demonstrated in NAFLD rat models, may be the mechanism by which some bacteria inhibit progression from benign hepatic steatosis to NASH. Changes in the microbiome may thus influence an individual's risk of developing NAFLD, progressing to NASH, or developing the metabolic syndrome.

Hepatic de novo lipogenesis (DNL) is the biochemical process of synthesising fatty acids from acetylCoA subunits produced by a variety of cell pathways, most notably carbohydrate catabolism.

In addition to glucose, which is the most common source of carbon units for DNL, fructose is a profoundly lipogenic substrate that can drive DNL, which is significant given the increased use of fructose in corn syrup as a sweetener.

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In eukaryotes, mRNA is transcribed in the _______ and then transported to the cytoplasm for translation

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Answer:

Nucleus

Explanation:

This is in reference to the central dogma of biology: DNA --> RNA --> Protein. DNA is replicated and then transcribed into RNA (which is where it becomes mRNA) which is then sent to a ribosome which is then translated and then created into protein.

Another definition of central dogma of biology is:

(transcribed)Transcription --> Translation --> Protein

The fastest known "cruiser" is the a bonito b yellowfish tuna c grouper d flounder

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yellowfish tuna

This is the fourth fastest fish, having recorded swimming speed of 76km/h.

What is Tuna known for ?

Tuna are remarkable and impressive wild animals. The Atlantic bluefin can reach ten feet in length and weigh as much as 2000 pounds (more than a horse)

Their specialized body shape, fins and scales enable some species of tuna to swim as fast as 43 miles per hour. Tuna swim incredible distances as they migrate.

The latest report by the UN shows that tuna is the world's most consumed and the second most wild caught fish in the world.

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what will happen in absence of semilunar valves?​

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Answer:

The absence of semilunar valves could cause a fetal death or induced abortion.

Explanation:

Severe regurgitation in both great arteries leads to volume overload in both ventricles, which causes fetal hydrops and death.

Hope this helps!

A Review of Global Prevalence and Economic Impacts of Infectious Bovine Keratoconjunctivitis AND doi

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The consequences of infectious bovine keratoconjunctivitis (IBK) on the economy call for more research into how Moraxella bovis colonizes and lives on the corneal surface.

What is the review of Global Prevalence and Economic Impacts of Infectious Bovine Keratoconjunctivitis and doi?

M. bovis strains that are virulent generate hemolysin and have unique plasmid profiles from nonvirulent strains. IBK prevalence is impacted by interactions between the host, environment, vector, season, and concomitant infections.

The illness process could be accelerated or made worse by Mycoplasma sp. or the infectious bovine rhino tracheitis virus. IBK symptoms can range from a minor case of conjunctivitis to severe ulceration, corneal perforation, and blindness. Economical factors, planned animal usage, and administration practicality all influence how IBK is treated.

The goal of antibiotic therapy is to increase medication concentrations in tears to levels that are at or above the minimum inhibitory concentration for extended periods of time. IBK is currently a disease that cannot be prevented. Vector control must be rigorously implemented and affected animals must be removed from the herd. Identification and exclusion of carrier animals from the herd are required.

Due to pili antigen cross reactivity, fluctuating strains, and unmanaged environmental conditions, vaccination efforts have been unsuccessful. Recent studies have revealed that M. bovis may use siderophores and iron-repressible outer membrane proteins to exploit host iron sources for growth. Understanding the typical defense mechanisms of the bovine eye may help develop innovative methods for boosting the immune response against M. bovis.

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Of the five known human sensory systems, which type of hallucination is the most common?

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Auditorial (or hearing voices). There’s actually an illness in which the main symptom is hearing voices.

Starting with one molecule of glucose, the energy-containing products of glycolysis are?

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Starting with one molecule of glucose, the energy-containing products of glycolysis are 2 NADH, 2 pyruvate, and 2 ATP.

A cytoplasmic mechanism called glycolysis converts glucose into two molecules with three carbons each and releases energy. Hexokinase, a phosphorylating enzyme, assists in the phosphorylation process that traps glucose. This reaction uses adenosine triphosphate (ATP), and the end result, glucose-6-P, inhibits hexokinase.As the name implies, glycolysis is the conversion of glucose to pyruvate. Two molecules of pyruvate are created for each molecule of glucose that enters glycolysis because pyruvate is a three-carbon molecule and glucose is a six-carbon molecule. Without oxygen, glycolysis takes place in the cytoplasm of the cell. Two ATP are produced per gram of glucose as net energy.

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____________________ syndrome occurs when the tendons of the wrist become inflamed and swollen.

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The tendons in your wrist are impacted by the painful ailment known as De Quervain's tenosynovitis. It happens when the two tendons near the base of your thumb swell up. The sheaths (casings) that surround the tendons become inflamed as a result of the swelling. This causes pain and numbness by pressing on adjacent nerves.

The additional symptoms:

Swelling close to the thumb's base. The backs of your thumb and index finger are numb. A sensation of "catching" or "snapping" as you move your thumb. As the tendons move inside the bulging sheaths, there is a squeaking sound.

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What technique uses a series of criteria and questions referring to physical characteristics to narrow down and determine the classification or name of a species?

A. Classification

B. Phylogenetics

C. Dichotomous Key

D. Binomial naming


abc or d with a simple explanation

Answers

Dichotomous key is the technique which uses a series of criteria and questions referring to physical characteristics to classify species.

What is Dichotomous key?

This was created by scientists to help classify different types of species in the ecosystem.

This employs the use of questions to contrast species in order to look for similar features to group them.

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Which information can be used to determine an atom's identity?

Counting the number of electrons

Counting the number of electrons

Counting both neutrons and electrons

Counting both neutrons and electrons

Counting the number of neutrons

Counting the number of neutrons

Counting the number of protons

Answers

The information that can be used to determine an atom's identity is the number of protons.

What is the proton number?

The proton number of an atom is the number of positively charged particles in the core of the atom.

The number of protons is always equal to the number of electrons for every neutral atom.

Thus, the proton number is the primary characteristic that can be used to determine the identity of an element.

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similarities in DNA, anatomical structures, and embryological development support common ancestry and evolution. true or false?

Answers

Answer:

true

Explanation:

Which events occur during the atrial contraction and ventricular filling phase of the cardiac cycle?

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Blood flows from the atria to the ventricles during ventricular diastole, and from the ventricles to the pulmonary artery and the aorta during ventricular systole during the cardiac cycle .

The cardiac cycle is a sequence of electrical and mechanical events that take place when the heart is contracting and relaxing (diastole) (systole). Blood flows from the atria to the ventricles during ventricular diastole, and from the ventricles to the pulmonary artery and the aorta during ventricular systole.The atrial musculature begins to contract with atrial depolarization. The pressure inside the atrial chambers rises as the atria contract, pushing more blood across the open atrioventricular (AV) valves and causing a quick flow of blood into the ventricles.The atria relax (atrial diastole) and receive venous return from both the body and the lungs during ventricular contraction. The lower chambers then loosen up during ventricular diastole, enabling initial passive filling of of the thick-walled ventricles and emptying of the atria.

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As a social worker employed in a mental health center, cecilia is most likely to consult the ___, a tool for assessing behavioral disorders.

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As a social worker employed in a mental health center, Cecilia is most likely to consult the DSM-IV-TR, a tool for assessing behavioral disorders.

DSM-IV-TR provides diagnostic criterion sets to help guide a clinician toward a correct diagnosis and an additional section devoted to differential diagnosis when persons meet diagnostic criteria for more than one disorder.

The intention of this information is to help the clinician determine which particular mental disorder is present, the identification of which would hopefully indicate the presence of a specific pathology and suggest a specific treatment.

It is evident, however, that DSM-IV-TR routinely fails in this goal, despite the best efforts of the leading clinicians and researchers who have authored the manual.

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A person's blood type is determined by?

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Answer:

your blood group is determined by the genes you inherit from your parents

You have stumbled on a new species of fly (order Diptera), and being a geneticist, you have already deritifled a few genes and observed an unusual phenotypic inheritance pattern. You have noticed that some flies have wings pointing forward and other flies have wings pointing backward. Digging in a bit deeper, you discover that the gene wing direction will controls which direction the wings point, and that if you cross homozygous backward-wing mother (wdir wall with a homozygous forward-wing father (wdir wer), all of the offspring (wdir wdin) have backward wings. When you perform the reciprocal cross, a homozygous forward-wing mother (wdi wdld with a homozygous backward-wing father (wdir wald, you observe that all of the offspring (wair wdir) have forward-facing wings. How would you account for this bizarre genotype phenotype relationship? a. Wing direction exhibits codominance where both phenotypes are represented equally b. The wdr gene is pleiotropic and affects multiple characteristics of the offspring causing the strange genotype phenotype relationship c. Wing direction is affected by something in the environment and is therefore an epgenetic trail Only the matemal gene for wing direction is being expressed due to genomic imprinting that silences the paternal gene during gamete formation d. Wing direction is obeying Mendes tws of independent assortment and segregation, therefore there is a 50/50 chance that wings will taco forward or backward in each offspring

Answers

Genomic imprint is the inactivation or silencing of one allele while the other one is still expressed. Option D). Only the maternal gene for wing direction is being expressed due to genomic imprinting.

What is the genomic imprint?

Genomic imprint or allele inactivation is the process through which one of the alleles of a gene (the one coming from the mother or the father) is suppressed, and only the other allele can be expressed.

This is not a mutation but a silencing effect due to other external factors. The unequal functional paternal and maternal genomes characterize the Genomic imprint pattern.

In the exposed example, Males' chromosomes are inactive or imprinted and have a different function from those females' chromosomes.

This is a common pattern in some mammals, insects, and angiosperms. The paternal allele can not be expressed, which causes an unequal contribution to the phenotype of the progeny.

Available data:

Diallelic Gene: Wdir ⇒ controls the direction of the wingwdir wdir ⇒ backwardwdir-wdir- ⇒ forwardwdir wdir- ⇒ backward or forward

1st cross:

Parentals) wdir wdir female (backward) x wdir- wdir- male (forward)

F1) 100% wdir wdir- (backward)

2nd cross:

Parentals) wdir wdir male (backward) x wdir- wdir- female (forward)

F1) 100% wdir wdir- (forward)

In both cases, the offspring is heterozygous for the trait but expresses the female's phenotype.

Only the maternal gene for wing direction is being expressed due to genomic imprinting that silences the paternal gene during gamete formation. Option D) is correct.

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You have stumbled on a new species of fly (order Diptera), and being a geneticist, you have already deritifled a few genes and observed an unusual phenotypic inheritance pattern.

You have noticed that some flies have wings pointing forward and other flies have wings pointing backward. Digging in a bit deeper, you discover that the gene wing direction (Wdir) will controls which direction the wings point, and that

if you cross homozygous backward-wing mother (wdir wdir) with a homozygous forward-wing father (wdir- wdir-), all of the offspring (wdir wdir-) have backward wings.

if you perform the reciprocal cross, a homozygous forward-wing mother (wdir- wdir-) with a homozygous backward-wing father (wdir wdir), you observe that all of the offspring (wdir wdir-) have forward-facing wings.

How would you account for this bizarre genotype phenotype relationship?

Multiple Choice

a) Wing direction exhibits codominance where both phenotypes are represented equally

b) The wdir gene is pleiotropic and affects multiple characteristics of the offspring causing the strange genotype phenotype relationship

c) Wings direction is affected by something in the environment and is therefore an epgenetic trail

d) Only the maternal gene for wing direction is being expressed due to genomic imprinting that silences the paternal gene during gamete formation

e) Wing direction is obeying Mendes tws of independent assortment and segregation, therefore there is a 50/50 chance that wings will taco forward or backward in each offspring.

A large area undergoes the same amount of metamorphism. All rock reach the same metamorphism grade. However, after the metamorphism some rocks are marble and some rocks are slate. Why?

Answers

The only explanation in this situation is that the parent rocks of the marble and slate were different. This indicates that the region once held both shale and limestone before metamorphism.

In reference to rocks, it denotes those that have undergone metamorphism—rocks that may have started as sedimentary, igneous, or another type of metamorphic rock but has since undergone "recrystallization" and taken on an entirely new form—under new temperature and pressure conditions.

For instance, when limestone is heated and compressed, it changes into marble, a more coarsely crystalline and occasionally banded rock.

When shale, a clay-rich, soft rock, is compressed, slate, a tougher rock, is created.

The alterations are frequently even more remarkable, resulting in the formation of new minerals, including garnet, mica, and tourmaline (as seen in schist).

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In green vegetables, such as broccoli, the orange pigments of provitamin A carotenoids are masked by

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In green vegetables, such as broccoli, the orange pigments of provitamin A carotenoids are masked by lycopene.

What is lycopene good for?

Strong antioxidant lycopene has a number of positive health effects, including as better heart health, reduced risk of certain cancers, and protection from the sun. Although it is available as a supplement, eating lycopene-rich foods like tomatoes and other red or pink fruits may be the best way to get the greatest benefit.

What is the side effects of lycopene?

Low blood pressure, an increased risk of bleeding, and digestive problems are some possible negative effects . There have been cases of lycopenaemia, a condition when eating a lot of lycopene-rich foods causes the skin to turn orange .

Which of the following is best for preserving the vitamin content of food?

Storing food in the pantry is the best way to preserve its vitamin content. Antioxidants are compounds that protect the body against damage from free radicals.

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The flowers that alisoun is compared to - primroses and pig's eyes - as well as the joke she plays on absolon all emphasize what aspect of her character?

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Flowers that Alisoun is compared to - primroses and pig's eyes - as well as the joke she plays on Absolon all emphasize her as a lustful young thing, says the narrator.

Just as she's a piggesnye "fit" to be laid in a lord's bed and a colt ready to be tamed.

These metaphors have the effect of turning Alisoun into an object that's meant to be ravaged by the men around, rather than a person who makes her own decisions about her sexuality.

Alisoun's character borrows a lot from misogynistic stereotypes about women, which portrayed them as dangerously lustful liars and cheats.

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There is a major difference between homeostasis and allostasis. Sterling and Eyer (1988) coined the term allostasis to mean that

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The primary explanatory framework for physiological control, homeostasis, has undergone major adjustment in recent years, with modern models varying greatly from the original formulation.

Allostasis, a different perspective on physiological control, extends beyond its homeostatic foundations, providing unique insights pertinent to our understanding and treatment of a variety of chronic health disorders. Despite increased interest in allostasis, the notion remains ambiguous, in part because of uncertainty in how the term is defined and used, hindering effective translational and clinical research on allostasis.

The processes behind physiological regulation and dysregulation are anticipated to have significant health and disease consequences.

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Why are dark green vegetables such as kale and spinach good sources of vitamin a?

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dark green vegetables such as kale and spinach good sources of vitamin A because they are rich in beta-carotene, which is retinol's precursor. Free radicals are made more stable by antioxidants by giving their unstable atoms an electron.

Normal growth and development, the immune system, reproduction, and vision all depend on vitamin A. Your heart, lungs, and other organs function normally with the aid of vitamin A. Yellow, orange, and red fruits and vegetables are colored by carotenoids, which are pigments.Yellow, red, and green (leafy) vegetables including spinach, carrots, sweet potatoes, and red peppers are the main nutritional sources of beta-carotene. fruits that are yellow, like mango, papaya, and apricots.Carotenoids, which your body may convert into vitamin A, are abundant in spinach. C vitamin. This vitamin is a potent antioxidant that supports immune system and skin health.

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What type of human cells contain a half set of chromosomes?

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Haploid refers to the presence of a single set of chromosomes in an organism's cells.

In ____________ , a double-stranded RNA molecule separates into single strands. One of the strands prevents a complementary mRNA from being translated.

Answers

The answer is RNA interference

If you want to see something in fine detail, you should focus the light on which part of your retina?

Answers

If you want to see something in fine detail, you should focus the light the cornea. The lens works together with the cornea to focus light correctly on retina.

When light hit on retina special cells called photo receptors turn the light into electrical signals. The lens are the clear part of eyes behind the iris that help to focus light and image on retina to see something clearly.Lens is the important part of eye when it comes to focusing light so that we can see perfect clear image.

The retina is the most sensitive part which can effect by more light because retina convert incoming light into electrical impulse.

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For the next two problems, assume that you have type A blood and are heterozygous for this characteristic (AO). List all potential genotypes and phenotypes in the population, even if the % is zero

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All potential genotypes and phenotypes in the population are ;

AA, AB, BB, AO, BO, OO.

The phenotypes are type A,

type B, type AB, type O.

This is further explained below.

What are phenotypes?

Generally, the collection of observable traits that make up a person and are the product of their genetics and environment interacting.

In conclusion, The genetic make-up of an organism is what is meant when the word "genotype" is used in a general sense.

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Use the meanings of the prefixes and suffixes in the table to form words that will match these definitions

Answers

Answer:

Zoology: The study of animals

-----> Zoo- = related to animals

-----> -ology = study of

Chlorophyll: a green pigment located in plant leaves necessary for photosynthesis

-----> chloro- = green

-----> -phyll = leaf

Microscope: an instrument used to view small objects

-----> micro- = small

-----> -scope = instrument for viewing

Multicellular: having many cells

-----> multi- = many

-----> -cellular = having to do with cells

Hydrolysis: when a chemical breaks when reacting with water

-----> hydro- = related to water

-----> -lysis = a releasing, loosening, or breaking

Osteopathy: a branch of medicine involving the treatment of diseases through manipulation of the bones, muscles, and/or joints

-----> osteo- = bone

-----> -pathy = suffering, disease

Photosynthesis: the process by which organisms use light to put together food made up of carbon dioxide and water

-----> photo- = light

-----> -synthesis = to put together

Excretion: the process of separating/expelling waste from the body

-----> ex- = out

-----> -cretion = the process of separating

Macrophyte: a plant large enough to be seen by the human eye

-----> macro- = large

-----> -phyte = plant

Biometer: an instrument used to measure evolved carbon dioxide in an effort to detect life

-----> bio- = life

-----> -meter = instrument used to measure

______ results in genetically identical daughter cells, whereas ______ results in genetically different daughter cells.

Answers

Identical daughter cells are produced as a result of mitosis whereas meiosis results in the formation of the daughter cells which are different genetically.

Mitosis and Meiosis are the stages of the cell cycle which can be further divided into stages called prophase, metaphase, anaphase and telophase. Mitosis results in the formation of two diploid daughter cells which genetically identical to the initial parent cell.
In the process of meiosis, the DNA gets exchanged between the chromosomes that are paired. This shuffling of DNA results in the formation of daughter cells after cell division which are genetically dissimilar.

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The _________________ is composed of and endothelial layer that is continuous with the endocardium of the heart.

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The tunica media is composed of an endothelial layer that is continuous with the endocardium of the heart.

What is tunica media?

Collagen, elastin, and smooth muscle cells make up tunica media. It is located halfway between the tunica externa and the tunica intima. The transverse arrangement of its strands and color make the middle coat (tunica medium) distinct from the inner (tunica intima). It not only supports the vessel but also alters the vessel's width to control blood pressure and flow.

Elastic fibers make up the majority of the tunica media in bigger vessels. The number of elastic fibers reduces as arteries get smaller, whereas the number of smooth muscle fibers grows. The strongest of the three layers is the tunica adventitia, which is the top layer. Elastic and collagenous fibers make up its structure.

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A woman is admitted to the labor suite with contractions every 5 minutes lasting 1 minute. she is postterm and has oligohydramnios. what does this increase the risk of during birth?

Answers

In that situation the risk of cord compression during the child birth. Serious umbilical cord problems can result in brain damage or the death of baby.

Umbilical cord occurs when the baby weight on the placenta or the vaginal walls put pressure on the cord during pregnancy labor or delivery. Cord compression during pregnancy is common problem. Sing of umbilical cord compression may include less activity form the bay observed as a decrease in movement or an irregular heart beats.

Umbilical cord compression is a medical term used to describe a condition in which a baby's umbilical cord becomes flattened by pressure of the baby.

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A client is admitted with cellulitis and experiences a consequent increase in white blood cell count. during what process will pathogens be engulfed by white blood cells that ingest foreign particles?

Answers

During phagocytosis, pathogens are engulfed by white blood cells that ingest foreign particles.

In addition to being present in practically every type of cell in multicellular species, phagocytosis is a fundamental function for nourishment in unicellular creatures. But only a specific class of cells known as professional phagocytes are highly effective at phagocytosis. These specialized cells include osteoclasts, neutrophils, monocytes, dendritic cells, and macrophages. Professional phagocytes are in charge of clearing pathogens from the environment and presenting antigens to lymphocytes to trigger an adaptive immune response. Fibroblasts, epithelial cells, and endothelial cells are referred to as non-professional phagocytes since they are only capable of performing phagocytosis with poor efficiency.

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Which muscle is highlighted? brachioradialis extensor carpi radialis brevis extensor carpi radialis longus pronator teres

Answers

The muscle which is highlighted in the diagram provided in the question is  referred to as brachioradialis and is therefore denoted as option A in this context.

What is a Muscle?

These are characterized by the presence of soft tissues which contract in other to exert a force. It is also involved in performing various types of activities for our daily living and survival such as eating, ,lifting of objects etc.

The brachioradialis is a muscle which is present in the forearm and helps in its flexion movement at the elbow region. The origin of this type of muscle is at the lateral supracondylar ridge of the humerus and performs other functions such as pronation and supination.

This is therefore the reason why brachioradialis was chosen as the most appropriate choice.

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What intensity (percent of 1RM) is most closely associated with the training adaptation of muscle hypertrophy? Less than 67 percent of 1RM 67 to 85 percent of 1RM Greater than 85 percent of 1RM 75 to 85 percent of 1RM

Answers

The intensity which is most closely associated with the training adaptation of muscle hypertrophy is 67 to 85 percent of 1RM and is denoted as option B.

What is Hypertrophy?

This type of muscle growth is observed in the enlargement of its overall size and volume as a result of various forms of stimuli such as external force from different types of load etc.

When performing exercises, load is carried by the muscles which increases its tendency to expand due to the stimulation of more structural proteins to the area as a result of it being stretched. This is however optimal when the individual attains about 67 to 85 percent of one-rep max when performing physical activities.

This is therefore the reason why option B was chosen as the most appropriate choice.

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Aperson invest 10,000 shillings for 40 months compounded monthly. Find the accumulated amount If the rate is 5% per annum. Using above information, Write a prolog program to answer the following queries. Please note that you cannot simply answer these queries with only facts, you should answer then using facts and rules Which theorist coined the term collective unconscious to refer to the impersonal, deepest layer of the unconscious mind, shared by all humans because of their common ancestral past? solve this two questions with explaining method also.... In order for css to work with HTML5 elements, you need to use a javascript HTML5 shiv or shim. What is this placed in? A neurotransmitter binds to a metabotropic receptor and pka is ultimately activated, which type of neurotransmitter likely bound? A tank of water contains 35 liters of water that leaks 6 liters of water an hour another container contains 29 liters of water that leaks 3 an hour if no the the tank and container start leaking at the same time how long does it takes for both the tank and container to have the same amount of water Spence recently graduated from high school. He is learning to be a drywaller by working with Phillip, who has more than a decade of experience in the trade. After several years, Spence expects to apply for jobs in the field on his own, then, one day, perhaps start his own business. Spence's current training exemplifies: work out the area of a rectangle with base, b = 20mm and perimeter, p = 50mm. Mike has started taking a yoga class. in what ways could this help improve his physical fitness? can someone please fill this out for me What are the coordinates of the midpoint of the segment whose endpoints are C(7, 10) and D(3, 9) ?(2, 0.5)(4, 1)(5, 9.5)(8.5, 3) Which of the following changes would increase the force between twocharged particles to 9 times the original force?A. Decreasing the distance between the particles by a factor of 3B. Decreasing the amount of charge on one of the particles by afactor of 9C. Increasing the distance between the particles by a factor of 3D. Increasing the amount of charge on each particle by a factor of 9 Rewrite 1/2 x 1/2 x 1/2 as an exponential expression with a base of 2. Find the missing segment in the image below. The change in equity of a business enterprise during a period from transactions and other events and circumstances from nonowner sources is called:_______ Jared tends to display his weaknesses and downplay his positive characteristics. With whom is he is likely to prefer to spend time Which concept describes the idea that government and government officials are not above the law? which words in this excerpt from macbeth represent the idea that duncans murder is a disruption of order Interstellar dust is effective at blocking visible light because Choose one: A. the dust is so dense. B. dust grains are so small. C. dust grains are so large. D. dust grains are so few.