Reduced microglial immunoreactivity for endogenous NMDA receptor agonist quinolinic acid in the hippocampus of schizophrenia patients

Answers

Answer 1

Postmortem and positron emission tomography have shown that microglial cells play a pathophysiological role in schizophrenia.

Reduced microglial immunoreactivity for endogenous NMDA receptor?

We postulated that the previously mentioned glutamatergic impairments in the hippocampus of schizophrenia patients may be related to the microglial synthesis of quinolinic acid (QUIN), an endogenous N-methyl-d-aspartate receptor (NMDAR) agonist. Reduced microglial immunoreactivity for endogenous NMDA receptor agonist quinolinic acid in the hippocampus of schizophrenia patients. We measured the number of QUIN-immunoreactivity microglial cells in the CA1, CA2/3, and dentate gyrus (DG) regions of the posterior hippocampus formation in schizophrenia patients and matched controls. HLA-DR, a popular microglial surface marker, was further immunostained in nearby histological sections. In the CA1 hippocampus sub region of schizophrenia patients compared to controls, fewer QUIN-immunoreactivity microglial cells were seen (left p=0.028, right p=0.018). In the CA2/3 and DG areas, no notable diagnosis-dependent alterations were seen. Potential confounding factors such as age, disease duration, autolysis time, psychotropic medication, and hippocampus volume were taken into account while analyzing these results. There were no variations in the overall density of microglial cells linked to diagnosis (HLA-DR expression). Our results imply that schizophrenia is related with decreased microglial QIUN content in the hippocampus CA1 region. We surmise that this connection could be a factor in schizophrenia patients' hippocampus' decreased glutamatergic neurotransmission.

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Related Questions

Antelopes and elephants feed on the same species of grasses and shrubs in a savanna and the fitness of each species is reduced when they co-occur. What form of species interaction occurs between the antelopes and elephants

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Interspecific competition occurs between antelopes and elephants.

The term "competition" refers to the process that takes place among many species as they fight for the same limited resources in order to maintain their own existence. This struggle over resources occurs among organisms because these species occupy niches that overlap, and as a result, they are compelled to use the same resources like food, water, and shelter.

Competition can be either interspecific or intraspecific. The term "interspecific competition" refers to a type of competition that occurs between various species that live in the same biological area and are dependent on the same source of food.

In the question, both antelopes and elephants feed on the same grass and shrub species. Therefore they compete amongst themselves as a result of which their fitness is reduced.

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The central nervous system consists of the: Group of answer choices parasympathetic and sympathetic divisions. sense organs and sensory neurons. brain and the spinal cord. muscles and glands.

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According to the research, the central nervous system consists of the brain and the spinal cord (c).

What is the central nervous system?

It is made up of the brain and spinal cord, these are the main information and control centers of the body.

The brain is the organ contained within the skull, which integrates and controls all the functions of the body, from the sensory, motor and integrative part.

Therefore, we can conclude that according to the research, the central nervous system consists of the brain and the spinal cord (c).

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The oldest true fossils are trace fossils called ___________________________ found in australia, and dated between 3.5 to 3.3 billion years old.

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The oldest true fossils are trace fossils called Stromatolites found in Australia, and dated between 3.5 to 3.3 billion years old.

Raphael Baumgartner and their team have finally uncovered evidence of organic matter in the ancient rock formations known as stromatolites found at the Dresser Formation fossil site in the Pilbara region of Western Australia. They detail their findings in a new article published in the journal Geology.

With a variety of methods, including scanning electron microscopy, scanning transmission electron microscopy, energy dispersive X-ray spectroscopy, Raman spectroscopy, nano-scale secondary ion mass spectrometry, and stable carbon isotope analysis, the researchers examined the samples in thin slices.

According to the team's analyses, pyrite, a mineral with many tiny pores, makes up the majority of the stromatolites. Additionally, the pyrite contains nitrogen-bearing organic material and strands and filaments of organic material that closely resemble the remains of microbial biofilm colonies.

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Consider the table below that summarizes the types of materials that can block the 3 different types of radiation.

Material
1
2
3
Lead Stopped Stopped Stopped
Cloth Not stopped Stopped Stopped
Aluminum foil Not stopped Stopped Stopped
Wood Not stopped Stopped Stopped
Paper Not stopped Stopped Not stopped
Thick concrete Stopped Stopped Stopped

Based on the table, at which numbered spot in the table does each type of radiation belong?
1 = beta; 2 = alpha, 3 = gamma
1 = alpha; 2 = beta, 3 = gamma
1 = beta; 2 = gamma, 3 = alpha

Answers

From the table, we can see that;  1 = beta; 2 = alpha, 3 = gamma. Option A

What is radiation?

Radiation is a form of energy that can not be seen. We know that beta radiation can be stopped by such things as a piece of cloth while alpha particles can be stopped by an aluminums foil. Also, gamma rays can only be stopped by thick concrete or lead.

Hence; we can conclude that; 1 = beta; 2 = alpha, 3 = gamma. Option A.

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