What are the features of Nuclear Receptor Screening Services?

Nuclear receptors (NRs) are a class of proteins responsible for thyroid hormones and sensing steroid and certain other molecules. There are 48 genes in the human genome that code for the NRs. As the largest family of eukaryotic transcription factors, NRs control numerous processes involved in development, cell cycle, and important metabolic pathways.

https://dda.creative-bioarray.com/nuclear-receptor-screening.html

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Answer 1

Answer:

The nuclear receptor superfamily comprises a large group of transcription factors that play a key regulatory role in development and homeostasis of multicellular organisms. A special feature of nuclear receptors is their ability to bind to condensed chromatin templates, which makes them important initiators of gene transcription. Moreover, the ability of nuclear receptors to sequentially recruit a variety of transcription factors and coregulators to target promoters and to orchestrate the whole process of gene transcription confirms their biological significance and stimulates intensive research and a high level of scientific interest in this field. In this review, we summarise current knowledge regarding the structure and function of nuclear receptors as principal regulators of gene expression. Emphasis is given to the molecular mechanisms of nuclear receptor-mediated transcriptional activation and repression including recent progress made in this area.


Related Questions

General and Specific knowledge example

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The sky is blue, Planes travel because of the pressure under the wings

GENERAL: the sky is blue SPECIFIC: Planes travel because of the pressure under the wings

Aquatic organisms in coastal areas face a variety of predators on land and in the water and air. Which ocean process exposes the coastal aquatic organisms to land-based predators? a. Changing wind patterns alter the ocean currents, changing tide levels. b. Daily tidal patterns leave areas exposed to the land for part of the day. c. The constant wave action generates nutrients that attract predators. d. The ocean conveyor belt raises and lowers the water levels on the coasts.

Answers

Answer:

b

Explanation:

The correct answer as to the ocean process that exposes the coastal organisms to land-based predators would be the daily tidal patterns that leave the coastal area exposed to the land for a part of the day.

Some parts of the coastal areas become exposed to land during certain periods of the day as a result of tidal waves. When this happens, the aquatic organisms occupying these coastal areas become temporarily exposed to land predators who hunt and kill them for food.

Therefore, the correct option is b.

Gene X always produces the same mRNA (one splice form) and the same protein in all cells in which it is expressed. The same amounts of gene X mRNA and protein are present in brain, kidney, and heart cells. However, the activity associated with the protein is present only in the heart. Which of the following are possible explanations?

a. A splicing factor necessary for removing all of the primary transcript's introns is present only in the heart.
b. A splicing factor necessary for removing all of the primary transcript's introns is present only in the brain and kidney.
c. Protein X is phosphorylated only in the heart.
d. Protein X is phosphorylated only in the brain and kidney.

Answers

There are two explanations for this phenomenon: phosphorylation of the protein X in the heart activates its function (Option C) or phosphorylation of the protein X in the kidney and the brain deactivates its function (Option D). Therefore, both Option C and Option D are correct.

Phosphorylation is a posttranslational protein modification that is capable of activating or deactivating protein function.

Phosphorylation alters the three-dimensional structure of a protein, thereby modifying its function (i.e., activate or deactivate the target protein).

Phosphorylation occurs at specific amino acids (e.g., serine and threonine residues) of the target protein.

Moreover, mRNA splicing (RNA processing) occurs before the protein state, it is a transcriptional process. This process consists in removing the non-coding regions or 'introns' from pre-mRNA and subsequent joining protein-coding regions or 'exons' to enable the translation of the mRNA into a protein.

In consequence, in this case, it is possible that 1-phosphorylation of the protein X in the heart activates its function, or 2-phosphorylation of the protein X in the kidney and the brain deactivates its function. Therefore, both Option C and Option D are correct.

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Why do roosters hibernate?

Answers

Answer:

The answer is

Explanation:

Roosters hibernate to escape the harsh seasonal variations as it cannot fly to different lands and is a flightless bird.

Hope this helps....

Have a nice day!!!!

Give five differences in the alimentary canal of flatworms earthworm and cockroaches

Answers

Answer:

Animals are adapted to the complex chain food since when they were no manufactured to the their food system. Without breakdown this complex food chain can not digest without breakdown.

Explanation:

Earthworm alimentary canal:

Earthworm have a segmentation of well developed characteristics of all animals. The alimentary canal of earth worm as well as flatworm consists of buccal cavity, mouth, esophagus, crop, intestines', gizzard, and anus. The digestion occur extracellular that means the digestion occur outside the cells. Cockroach is an omnivores. It ranging from starchy to the sweet things to the paper and clothes etc. It suits its diet. Its alimentary canal consists of Foregut, midgut and the hindgut. Both are different in their structure as well as in their alimentary canal.

three (3) advantages of using a resource person in handling the First Aid lesson.

Answers

Answer:

Advantages of resource person in handling the first aid lesson are as follows:

He is an expert who share important points during first aid and prevents any mishappening.They also provide assistance to the community member and provide social audits in villages.A resource person can share extreme difficult cases of injuries and will introduce new methods to adopt first aid in those conditions.

what is the formula for net primary productivity​

Answers

Gross Primary Production or GPP minus the carbon that is lost to respiration

Explanation:

NP = GPP - RESPIRATORY LOSS

When discussing magnetic fields we could say that
metals can become magnetic if they have many spinning electrons that create magnetic fields
O metals are magnets because they have more electrons than non-magnetic materials
O non-paired electrons spin in opposite directions creating a magnetic field
the spinning electrons in some atoms pair up and create a magnetic field

Answers

Answer:

Explanation:

metal can become magnetic if they have many spinning electron. When the majority of atoms spin in the same direction the strong magnetic field is produced the direction of electron spin determine the direction of magnetic field

_is a molecule that directs all of a cells activities

Answers

Answer:

[tex]\boxed{\mathrm{Nucleus}}[/tex]

Explanation:

The nucleus directs all cellular activities. The nucleus also contains genetic material of eukaryotic organisms.

If you insert a gene from bacteria into a mouse genome, then which terms best explains what you just made?

Answers

Answer:

a transgenic animal

Explanation:

What does cyclical mean

Answers

Cyclical means occurring in cycles technically meaning reoccurring.

The original name for Asian Homo erectus was Group of answer choices Homo rudolfensis. Australopithecus. Paranthropus. Pithecanthropus.

Answers

Answer: Pithecanthropus erectus.

Explanation:

Between 1891 and 1892 Eugène Dubois believed he had found the "missing link", hypothesized by Ernst Haeckel, when he discovered some loose teeth, a skull cap and a femur - very similar to that of modern man - in the excavations he was carrying out in Trinil, located on the island of Java, Indonesia. Homo erectus erectus was the first specimen of Homo erectus to be discovered.  Dubois first named it Anthropopithecus erectus and then renamed it Pithecanthropus erectus. The name Homo erectus means in Latin "erect man", wich means, "standing man", whereas Pithecantropus erectus means "standing ape-man".

So, Dubois published these findings as Pithecanthropus erectus in 1894, more popularly known as "Java Man" or "Trinil Man". In the 1930s the German palaeontologist Ralpf von Koenigswald obtained new fossils, both from Trinil and from new locations such as Sangiran and in 1938 von Koenigswald identified a magnificent Sangiran skull as "Pithecanthropus". It was not until 1940 that Mayr attributed all these remains to the genus Homo (Homo erectus erectus).

Lactose (milk sugar) is a carbohydrate that is formed by combining galactose and glucose. Which term best describes this molecule?

Answers

Answer:

disaccharide

Explanation:

A disaccharide is a form of sugar that is made up of the combination of two other sugar molecules that are simple. They possess the property to dissolve easily in water. The process that occurs to join the two simple sugars includes the removal of water from the molecules. Sucrose, lactose, and maltose are the three disaccharides.

Answer:

disaccharide

Explanation:

A disaccharide is a form of sugar that is made up of the combination of two other sugar molecules that are simple. They possess the property to dissolve easily in water. The process that occurs to join the two simple sugars includes the removal of water from the molecules. Sucrose, lactose, and maltose are the three disaccharides.

The client has experienced a stroke, and her speech is now garbled. The client may have experienced damage to which of the following?
A. Brainstem
B. Medulla oblongata
C. Frontal lobe
D. Cerebellum

Answers

Answer:

C

Explanation:

A person with garbled speech may have experienced damage to the frontal lobe portion of the brain.

This is because the left portion of the frontal lobe of the brain is an area that has been touted to be responsible for the control of speech in humans. Research in the past has shown that damage to that region of the brain affects the formation of spontaneous speech as well as motor speech control.

Hence, garbled speech in someone that has experienced stroke can be attributed to damage to the frontal lobe.

Correct option: C.

Discuss Connell and Slatyer three mechanisms of succession. Start your answer with a definition and an example of what is succession, and describe how succession begins.

Answers

Answer:

Facilitation, tolerance and inhibition models

Explanation:

J. H. Connell and R. O. Slatyer stated three different ecological succession models that explain how species composition may change by the effects of disturbances in the ecosystem. These models are as follow:  

1- Tolerance model: in this model, the new species don't affect the growth and success of existing species, thereby the process of succession is purely associated with life-history strategies.

2- Facilitation model: only 'ideal traits' found in colonizing species lead to the initial succession. These ideal traits include for example effective mechanism of dispersal, water storage tissues to survive in dry regions, long-term seed dormancy, etc.

3-Inhibition model: Species that appeared during early succession are capable of inhibiting growth of species appeared in later stages, as well as reduce colonizing species abundance.

Plaque formation in virus is done for :
a) Isolation and typing of virus
b) Cloning seperation of specific of virus
c) Determining infectivity of virus
d) Accessing multiplication of virus​

Answers

Answer:

I think the answer is determining infectivity of a virus

Explanation:

hope that it will help you

The gene encoding VEGFR2, the main receptor that binds and is activated by VEGF-A, is transcribed in almost every tissue type, but the VEGFR2 protein is rarely present. List and describe one mechanism that cells could use to reduce VEGFR2 protein levels despite high levels of transcription.

Answers

Answer:

The RNA interference (RNAi) mechanism

Explanation:

RNA interference (RNAi) is a biological process by which endogenous non-coding RNAs (ncRNAs) sequences target messenger RNAs in order to inhibit gene expression and translation. The regulatory ncRNAs bind by complementary base pairing to specific mRNAs and thus promote gene silencing by both posttranscriptional (mRNA degradation, block translation, etc) and by transcriptional (recruiting of histone/DNA modifying enzymes) pathways. The most common types of evolutionarily conserved ncRNAs found in plant and animal cells are 1-small interfering RNAs (siRNAs), 2-microRNAs (miRNAs), 3-piwi interacting RNAs (piRNAs, only present in animal cells) and 4-long noncoding RNAs (lncRNAs).

Describe your plan to preserve the biodiversity of the town's lake. Make sure to include the materials that you would need for your plan to work and how you would scale it up to test it.

Answers

Answer:

10 Ways to Protect and Conserve Biodiversity

Government legislation.

Nature preserves.

Reducing invasive species.

Habitat restoration.

Captive breeding and seed banks.

Research.

Reduce climate change.

Purchase sustainable products.

Provide one example of quantitative data that can be collected when using a microscope?

Answers

Answer: there 3 ducks by the pond

Explanation:

Quantitative is numbers. how many.

For every 100ml of deoxygenated blood delivers approximately _____ml of CO2 to the alveoli.​

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Answer:

For every 100ml of deoxygenated blood delivers approximately __4___ml of CO2 to the alveoli.

Answer:

4ml

Explanation:

For every 100ml of deoxygenated blood delivers approximately 4 ml of CO2 to the alveoli.

Hope it is helpful....

Help .....plz help me​

Answers

Answer:

Where is question. Hope you understand me

Explanation:

Please mark me brainliest thanks

PLEASE ITS URGENT!
Can someone help me name them!

Answers

Answer:

i filled the thing out for you. i didnt know what grade you were in so i just put the cell names in.

Explanation:

What are the
traditional
circulatory
endpoints of
resuscitation
in shock?​

Answers

Explanation:

traditional circulatory endpoints of resuscitation in shock include hypertension,tachycardia,decreased mentation and urine output

Please add the missing term:
Species -> Population -> Community
-> Ecosystem -> Biome ->
A. Ecology
B. Life Bubble
C. Hydrosphere
D. Biosphere
Copyright 2003 - 2021 Acellus Corporational

Answers

Answer:

Biosphere hope its a good one

g The ____ ring is built onto ribose-5-phosphate of PRPP for its de-novo nucleotide biosynthesis, while the ring structure of the ______ bases are synthesized separately and then coupled to ribose-5-phosphate via the C-N glycosidic bond.

Answers

Answer:

The purine ring is built onto ribose-5-phosphate of PRPP for its de-novo nucleotide biosynthesis, while the ring structure of the pyrimidine bases are synthesized separately and then coupled to ribose-5-phosphate via the C-N glycosidic bond.

Explanation:

Purines are produced as bases attached to the ribose 5-phosphate (pentose sugar). The adenine and guanine nucleotides derive from inosine monophosphate (IMP), which is synthesized on an existing ribose-phosphate. Thus, purine bases are built on a ribose sugar that is directly attached to the pyrimidine ring. On the other hand, pyrimidines are produced from the carbamoyl phosphate precursor. In this case, the ribose-5-phosphate pentose sugar is attached after the pyrimidine ring is made.

whats the answer guys help me out

Answers

Answer:

Read Exp:

Explanation:

1st one - Attracts Pollinators.

2nd one -  Prevents water loss.

3rd one - Traps insects.

In ______, Gorter and Grendel extract lipids from blood cells. After evaluating them, they propose membranes are made of a ____________.

Answers

Answer:

The correct answer would be - 1925, phospholipid bilayer.

Explanation:

Gorter and Grendel performed an experiment in 1925 to extract lipids from blood cell and after extracting the protein they evaluated red blood cell membrane.

They found out that plasma membrane have two lipid layer and these lipids are made of phospholipids. Phospholipids are phosphate group that are attached with the lipid molecule.

Thus, the correct answer would be - 1925, phospholipid bilayer.

When the body cells are hypotonic to the blood plasma, water will move from intracellular fluid to extracellular fluid.
A. True
B. False

Answers

Answer:

True

Explanation:

When neuroscientists employ the term "nucleus", they are usually referring to:_____.
​a. a cluster of glial cells in the dorsal-medial CNS.
​b. a neural unit composed of anatomically and functionally related neurons.
​c. a group of homologous ganglia located either in the cortex or in the cerebellum.
​d. cognitively synchronized clusters of apical dendrites anywhere in the PNS.

Answers

Answer:

B. A neural unit composed of anatomically and functionally related neurons.

The basal metabolism of a human adult is the total rate of energy production when a person is not performing significant physical activity.

a. True
b. False

Answers

Answer:

True

Metabolism refers to the countless chemical processes going on continuously inside the body that allow life and normal functioning.

The amount of kilojoules your body burns at any given time is affected by your metabolism.

Your metabolic rate is influenced by many factors – including age, gender, muscle-to-fat ratio, amount of physical activity and hormone function.

Hope this helps you ❤️

MaRk mE aS braiNliest ❤️^_^

Answer:

Explanation:

                FALSE

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